Engineering Saccharomyces cerevisiae for Increased Utilization of Xylose from Biomass
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چکیده
What problem does it address? Biomass feedstocks are composed of hexose and pentose sugars locked into a higher-order structure. The most abundant of these sugars are glucose and xylose. Strains have been engineered to utilize xylose, but these strains do not grow well when xylose is the only sugar available. Xylose uptake into the cell is one of the limitations to efficient xylose utilization. The strain developed here addresses the problem of poor xylose uptake in S. cerevisiae.
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Evolutionary engineering of Saccharomyces cerevisiae for efficient aerobic xylose consumption.
Industrial biotechnology aims to develop robust microbial cell factories, such as Saccharomyces cerevisiae, to produce an array of added value chemicals presently dominated by petrochemical processes. Xylose is the second most abundant monosaccharide after glucose and the most prevalent pentose sugar found in lignocelluloses. Significant research efforts have focused on the metabolic engineerin...
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